Dr. Kretzler is the Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics. The overarching goal of his research is to define chronic organ dysfunction in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he has developed a translational research pipeline centered on integrated systems biology analysis of renal disease.
He leads the U54 Nephrotic Syndrome Research Network (Neptune) in the Rare Disease Clinical Research Network II, is a Principle Investigator (PI) of the Coordinating center of the CureGN research network, the Director of the Applied Systems Biology Core, PI in the R24 “Integrated Systems Biology Approach to Diabetic Microvascular Complications” and site PI in the NIH Acceleration of Medicine (AMP) program in lupus.
He has 20 years of experience in integration of bioinformatics, molecular and clinical approaches in more than 210 publications. He has a track record on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the US, Europe, China and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, epigenetic markers, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanism identified have result in new disease predictors and successful phase II trial of a novel therapeutic modality in diabetic kidney disease.
Matthias Kretzler was born in Bruchsal, Germany close to Heidelberg (and France). He received his medical training at the University of Heidelberg, Germany; Newcastle upon the Tyne in the U.K.; and at the University of Michigan.
Taking full advantage of Germany’s medical training system, Matthias enrolled in an MD/PhD structured program working Wilhelm Kriz’s Anatomy and Cell Biology research team on the mechanism of glomerular filtration barrier failure. The fascination of the aesthetic beauty of glomerular filters has become the central theme of his research for the past 20 years. Beginning with ultrastructural morphology, he expanded his research efforts to modern molecular biology tools during a post-doctoral fellowship with Josie Briggs, MD, Juergen Schnermann, MD, and Larry Holzman, MD and the University of Michigan.
After returning to Germany he built, under the mentorship of Detlef Schlondorff, MD, a molecular nephrology laboratory at the Medizinische Poliklinik in Munich. Using the unique research team network around the European Renal Cell Study Group, he initiated what is now a worldwide network of kidney research centers to define molecular mechanism of renal disease in humans. For this personalized medicine approach to Nephrology he found an ideal environment at his old alma mater – the University of Michigan – and is now embedded in the fascinating collaborative network of molecular biologists, clinician-scientists, mathematicians, bioinformaticians, and systems analysts at work in Ann Arbor.
The love of his life, Annette, and his two children Katharina and Johannes, are very effective counterbalances to his busy life as a clinician-scientist and ensure he enjoys the wonders and beauties of Michigan’s nature.